Vitamin B12 works closely with folate in the body. Therefore, it is important in most cases to take these nutrients in combination. This product consists of 1000 mcg of vitamin B12 in the biologically active forms methylcobalamin and adenosylcobalamin (also known as dibencozide) and 500 mcg 5-methyltetrahydrofolate (5-MTHF). These are the forms in which vitamin B12 and folate are used by the body. In other products, vitamin B12 often appears as cyanocobalamin and folate as folic acid (pteroylmonoglutamic acid). These are synthetic forms that do not naturally occur and must be converted by the body into the biologically active forms. A problem with pteroylmonoglutamic acid is that a relatively large group of people has difficulty converting it into 5-MTHF. Therefore, Vitals uses Quatrefolic®, which consists of 5-methyltetrahydrofolate bound to glucosamine salt for stability and superior biological availability.

Functions of vitamin B12 and folate
Vitamin B12 in the form of methylcobalamin is needed for 5-MTHF to convert homocysteine into methionine (vitamin B6 is also involved in this process). A high homocysteine level is undesirable. Methionine is mainly used for the production of S-adenosylmethionine (SAMe), which as a methyl donor is involved in the production of, among other things, DNA, RNA, phospholipids, proteins, and neurotransmitters. Thus, vitamin B12 and folate are involved in the cell division process and are necessary for the production of red blood cells.

Due to the joint involvement of vitamin B12 and folate (and vitamin B6) in DNA synthesis and protein synthesis, these nutrients influence the activation of certain immune cells and thus the normal functioning of the immune system.

In the form of adenosylcobalamin (in the mitochondria), vitamin B12 is involved in the conversion of methylmalonyl-CoA into succinyl-CoA, which plays a role in the citric acid cycle (a series of biochemical reactions that provide energy metabolism at the cellular level). Vitamin B12 and folate are also necessary for normal brain and nerve functions, and thus are good for concentration, memory, and mood. Vitamin B12 and folate can also help reduce fatigue.

Sometimes, vitamin B12 is not well absorbed by certain people. In such situations, supplementing the diet with a high-dose B12 supplement can offer a solution. Due to the close collaboration with folate, it is advisable to combine these two vitamins. For optimal efficacy, this product is also combined with a multivitamin, where it is important not to exceed a total daily intake of folate of more than 1000 mcg with prolonged use (>3 months).

Other information

EAN: (100 lozenges) 8716717003303

Composition per lozenge: (daily dose) %RI*
Vitamin B12   1000 mcg   40000%
Of which:
methylcobalamin   500 mcg   20000%
adenosylcobalamin (dibencozide)   500 mcg   20000%
Folate (5-MTHF glucosamine salt, Quatrefolic®)   500 mcg   250%

* RI = Reference Intake

Quatrefolic® is a patented product and a registered trademark of Gnosis.

Ingredients:
Sweeteners (mannitol and xylitol, from plant source), bulking agent (hydroxypropylcellulose), anti-caking agent (magnesium salts of fatty acids), cherry flavour, acidity regulator (citric acid), 5-methyltetrahydrofolate-glucosamine salt, methylcobalamin, adenosylcobalamin.

Contains no:
Gluten, lactose, soy, GMOs, preservatives, and synthetic fragrances and colourings.

Suitable for vegetarians and vegans.

Allow 1 lozenge per day to dissolve under the tongue, or as advised. Contains sweeteners.

Excessive consumption may have a laxative effect.

This product is a food supplement (Vitamin preparation).  

Adhere to the recommended dosage.  

A varied, balanced diet and a healthy lifestyle are important.

A food supplement is not a substitute for a varied diet.  

Keep out of reach of young children.  

Store dry, sealed, and at room temperature, unless otherwise advised on the label.  

Consult an expert before using supplements in case of pregnancy, lactation, medication use, and illness.

Glucosamine

Glucosamine

Vitamin B6